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Characterization of CD45RO+ memory T lymphocytes in keloid disease

British Journal of Dermatology Apr 27, 2018

Chen Z, et al. - Experts probed the abnormalities of a specific memory T cell called CD3+CD45RO+ in keloid scars by analyzing blood and tissue samples. The authors, from Shanghai, China found that most of T lymphocytes in keloid scars were CD3+CD45RO+ memory T cells. They described the ways in which this type differs from another type of memory T cells called FOXP3-CD8-mT. In keloid scars, abnormalities were noted in the CD45RO+ memory T-cell subsets. Findings suggested that in the development of keloid scarring, dysregulation of T cell responses could play a role.
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