Szari S, et al. - Researchers intended to fine map thymic stromal lymphopoietin (TSLP; an immune regulator) as well as assess links with the commencement and persistence of atopic dermatitis (AD). In a longitudinal cohort of children with AD, they ascertained TSLP variation by using targeted massively parallel sequencing. They used a second independent cohort to assess the link between the presence of AD and rs1898671 variation. The minor variant frequency for rs1898671 was estimated to be 23.5%. In the longitudinal cohort (n = 741), this variant was not in linkage disequilibrium with other TSLP variants. Compared with a genomAD control, a less probability to have rs1898671 variant was observed in white children with AD. Compared with children who were wildtype for rs1898671, the likelihood of having a remission during follow-up was more in children with AD and the rs1898671 variant. A less prevalence of rs1898671 variant was reported in those with AD than those without in the second cohort (n = 585). In rs1898671 heterozygotes vs homozygotes, a greater protective effect was seen. Findings revealed the crucial role of TSLP and especially rs1898671 in the pathogenesis of AD, as well as its potential as a clinical target for the development of therapies to treat people with AD.