Li H, Wen Y, Liu P, et al. - In this cross-sectional study involving 88 postmenopausal women with newly diagnosed type 2 diabetes mellitus (T2DM) and 152 non-diabetic control people, researchers sought to identify bone turnover characteristics in patients with newly diagnosed T2DM who have never been treated with anti-diabetic drugs and to investigate the possible factors contributing to their impaired bone turnover. This investigation was carried out in Tongji Hospital, Tongji University School of Medicine, Shanghai, China from January 2019 to December 2019. Dual-energy X-ray absorptiometry was used to measure bone mineral density. Patients with T2DM had higher levels of bone alkaline phosphatase (BALP) and lower levels of procollagen type I intact N-terminal (P1NP), osteocalcin (OC) and parathyroid hormone compared with the control group. Multiple linear regression analysis revealed that HbA1c was negatively related to P1NP and OC in T2DM patients. HbA1c was found to be inversely related to BALP and OC in patients who did not have diabetes.