Molloy K, Jonak C, Woei-A-Jin FJSH, et al. - In patients newly diagnosed with mycosis fungoides (MF)/Sézary syndrome (SS), researchers identified factors correlated with poorer health-related quality of life (HRQoL). Using the Skindex-29 questionnaire, patients enrolled into Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI; an international observational study in MF/SS) had their HRQoL evaluated. Study participants included 237 patients, of whom 179 had early MF and 58 had advanced MF/SS. According to item-level analysis, the severe impairment in symptoms and emotions subscale scores seen in women was caused by more burning/stinging, pruritus, irritation and greater feelings of depression, shame, embarrassment and annoyance with their diagnosis of MF/SS. In newly diagnosed women with MF/SS and in those with alopecia, HRQoL is significantly more impaired. Since Skindex-29 does not include existential cancer questions that may cause additional worry and distress, a comprehensive validated T-cell lymphoma-specific questionnaire is urgently required to more accurately assess these patients' disease-specific HRQoL.