Zhang EW, Shepard JAO, Kuo A, et al. - This study attempted to test the characteristics and outcomes of screening detected lung cancers. Researchers designed a single institution retrospective study including lung cancer screening (LCS) patients between June 2014 and December 2019. They extracted patient demographics, number of screening rounds, imaging features, clinical work-up, disease extent, histopathology, treatment, complications, and mortality outcomes of screening detected lung cancers and compared with National Lung Screening Trial (NLST) data. In this study, 7,480 LCS low-dose CTs were conducted on 4,176 patients. This study’s findings demonstrate that LCS implementation achieved higher cancer detection rate, detection of early stage cancers, and more multifocal lung cancers compared to the NLST, with low complications and mortality. Impact: The findings suggested that the real-world implementation of LCS has been successful for detection of lung cancer with favorable outcomes.