Ogimi C, et al. - In view of the assumption that immunocompromised children might be predisposed to serious infections from human coronaviruses (HCoVs), including strains OC43, NL63, HKU1, and 229E, researchers here compared the virologic and clinical features of HCoV infection in immunocompromised children to those in nonimmunocompromised children. Findings revealed an increased risk for lower respiratory tract disease that necessitated oxygen use (severe LRTD) in association with the presence of a copathogen and host factors, including an immunocompromised state. In multivariable models, younger age, having an underlying pulmonary disorder, and the presence of respiratory syncytial virus were also associated with LRTD or severe LRTD.