Kumagai K, Fujimaki H, Yamada S, et al. - This study was attempted to explore the impacts of the high tibial osteotomy (HTO) on the biological status of knee osteoarthritis (OA) using joint markers in synovial fluid (SF). Researchers recruited a total of 50 individuals with medial compartmental OA of the knee who had undergone opening wedge HTO. They obtained paired SF samples from the affected knee and arthroscopic evaluation of articular cartilage at the time of HTO surgery and the time of plate removal (postoperative 17±4 months). For cartilage degradation and synovial inflammation, SF levels of biochemical markers were altered after HTO, implying an improvement in the OA disease state.