Liu W, Huang Z, Tang S, et al. - Using the nested case-control study method, researchers sought to examine the changes of serum sex hormone-binding globulin (SHBG), homocysteine (Hcy), and hypersensitive CRP (hs-CRP) levels during pregnancy and their relationship with gestational diabetes mellitus (GDM). Sixty nonobese single pregnant women with GDM were assigned to the GDM group (n = 60), while another 60 pregnant women with normal glucose tolerance were matched in the same period and assigned to the control group (n = 60). Increased Hcy and hs-CRP in the second trimester and lowered SHBG in the first trimester were independent predictors of GDM, suggesting a new strategy for GDM prevention and treatment.