Zhu Y, et al. - In the present study, the researchers examined the changes of inflammatory and oxidative stress responses in Henoch-Schönlein purpura (HSP; one of the most common systemic vasculitis in childhood) children and further analyzed the therapeutic impacts and mechanisms of hemoperfusion (HP) on HSP with severe gastrointestinal (GI) involvement. According to their clinical manifestations, 200 children with HSP were divided into three groups: 60 in HSP without GI and renal involvement group, 60 in HSP with GI involvement group, and 80 in HSPN group. According to results, IL-6, TNF-α and MDA levels in HSP were increased in each group compared with healthy group, while SOD and T-AOC were reduced. In the acute phase of HSP children, inflammatory and oxidative stress can be involved. The degree of renal involvement was associated with the intensity of inflammatory and oxidative stress responses. In children with severe HSP with GI involvement, HP can reduce glucocorticoid dosage and the rate of renal involvement. The mechanism may be related to the fact that in children with HSP, HP can effectively eliminate IL-6, TNF-α, MDA.