Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity
Graefe's Archive for Clinical and Experimental Ophthalmology Jan 17, 2018
Huang CY, et al. - The goal of this analysis was to examine the levels of vascular endothelial growth factor (VEGF) in the systemic circulation of patients with type 1 retinopathy of prematurity (ROP), who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB). Findings displayed a suppression of the serum VEGF levels and the VEGF/PLT ratio in such individuals for 3 months after treatment with either IVA or IVB. However, pronounced suppression of systemic VEGF was noted among patients treated with IVB than those treated with IVA.
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