Inanc M, et al. - Researchers conducted this cross-sectional prospective study to ascertain if abnormal glucose metabolism in diabetes mellitus (DM) influences the retinal microcirculation of children with well-controlled type 1 DM and to compare these outcomes with those obtained from healthy children. The sample consisted of 60 patients with DM without clinically detectable diabetic retinopathy (DR) and 57 age-matched control individuals. Using AngioVue (Avanti, Optivue), optical coherence tomography angiography (OCT-A) was performed. No significant associations were found between DM duration and HbA1c levels with the investigated OCT-A parameters. According to findings, diabetic eyes without clinically detectable DR showed alterations in FD-300, AI, perimeter, and vessel density of parafoveal capillaries in deep capillary plexus preceding the enlargement of foveal avascular zone. These new parameters, therefore, could be sensitive imaging biomarkers to define early DR.