Hernandez-Santiago V, et al. - In this population-based interrupted time series study, researchers analyzed changes in the community in the prescribing of broad-spectrum antimicrobials and resistance in people hospitalized with community-associated coliform bacteraemia relative to a primary care stewardship intervention. Findings revealed that a previously rising rate of fluoroquinolone resistance was reversed and previously increasing rates of cephalosporin and co-amoxiclav resistance plateaued. There were very large decreases in the use of community broad-spectrum antimicrobials linked with the stewardship intervention vs prior trends. On the other hand, there were more modest changes in resistance among coliform bacteremia. Resistance prevention through careful use of new antimicrobials may be more effective than attempting to reverse resistance that has already emerged.