Tang EC, et al. - Researchers here investigated kidney function associated with HIV preexposure prophylaxis (PrEP) using daily oral tenofovir-disoproxil-fumarate/emtricitabine in real-world clinical settings. Daily tenofovir-disoproxil-fumarate/emtricitabine PrEP resulted in reduced creatinine clearance and estimated glomerular filtration rate (eGFR). However, these eGFR changes were based on very small changes in serum creatinine and appeared to be nonprogressive after the first 12 weeks.