Turner J, et al. - Researchers examined how intrapartum sildenafil citrate (SC) administration affects fetoplacental blood flow indices. They conducted a subgroup analysis from an earlier phase 2 double blind randomized controlled trial examining the effect of intrapartum SC administration (50 mg orally 8 -hly in labour) vs placebo for the reduction of operative birth for intrapartum fetal compromise. Findings revealed despite non-significant differences in Doppler indices pre- and post- SC treatment, a clear trend towards a reduction in the umbilical artery (UA) pulsatility index (PI), a corresponding increase in the middle cerebral artery (MCA) PI and a rise in post treatment cerebroplacental ratio (CPR) values could be seen. This suggests potential improvement in fetoplacental Dopplers with intrapartum SC treatment. This hypothesis generating study thus yielded results suggesting the possibility to stratify women that would most benefit from this intervention based upon their pre-labour CPR.