Xi LF, et al. - Researchers intended to produce epidemiologic data on the clinical significance of viral load fluctuation of oncogenic types other than human papillomavirus (HPV) types 16 and 18. From women examined in a clinical trial and observed every 6 months for 2 years for the presence of HPV and cervical intraepithelial neoplasia grades 2 and 3 (CIN2/3), they randomly selected a type-stratified set of infections by non-HPV16/18 oncogenic types identified at ≥2 visits. Findings revealed an association of an increase in CIN2/3 risk with high vs low viral load at both first and last positive visits; they also noted that an increase in risk of CIN2/3 was marginally related to an alteration of viral load from low to high levels for infection by species group alpha-9 non-HPV16 oncogenic types but not species group alpha-5-7 non-HPV18 oncogenic types. Findings revealed differences in the viral load change-related risk of CIN2/3 by HPV species groups; this was in agreement with data on baseline viral load.