Xi LF, et al. - Given a limited epidemiologic data inscribing clinical significance of viral load fluctuation of oncogenic types other than human papillomavirus (HPV) types 16 and 18, researchers examined women who were enrolled in a clinical trial and were followed every 6 months for 2 years for detection of HPV and cervical intraepithelial neoplasia grades 2 and 3 (CIN2/3), for randomly selecting a type-stratified set of infections by non-HPV16/18 oncogenic types that were detected at ≥2 visits. At the last HPV-positive visit, confirmation of CIN2/3 was initially made for 67 of 439 infections. Risk of CIN2/3 was higher in association with high, relative to low, viral load at both first and last positive visits and there was a marginal association of the risk with a change of viral load from low to high levels for infection by species group alpha-9 non-HPV16 oncogenic types but not species group alpha-5-7 non-HPV18 oncogenic types. This suggests that differences in the viral load change–associated risk of CIN2/3 occur in correlation to HPV species groups thereby supporting data on baseline viral load.