Chen CPC, et al. - The impact of ventriculoperitoneal shunting surgery on cerebral spinal fluid (CSF) individual and total protein concentrations was assessed in geriatric normal pressure hydrocephalus (NPH) patients by using proteomics. Postoperatively, at least 2-fold increase in the protein concentrations associated with anti-oxidation, aging, and in the prevention of neurotoxic agent production was noted. This implied that the brain may become less susceptible to neurodegeneration. Overall, shunting surgery may be recommended for geriatric patients with confirmed diagnosis of normal pressure hydrocephalus.