Bragg AE, Crowe-White KM, Ellis AC, et al. - Framingham and Cardiometabolic Disease Staging (CMDS) risk scores were significantly more sensitive to changes in cardiometabolic risk than the other risk scores studied. Obese older adults can significantly reduce their cardiometabolic risk by combining exercise and weight maintenance or exercise and weight loss through moderate caloric restriction.

• Candidates (39% male, 23% African American, 70.2 ± 4.7 y) were randomly assigned to one of three groups: exercise (n = 48), exercise + nutrient-dense weight maintenance diet (n = 44), or exercise + weight loss by moderate caloric restriction (n = 42).

• Only Framingham and CMDS showed significant group-time interaction.

• Post-hoc analysis revealed significant within-group improvements in Framingham scores for exercise + weight maintenance and exercise + weight loss.

• Significant reductions were noted in the exercise + weight maintenance group vs the exercise group in the analysis of between-group differences in Framingham scores.

• For CMDS, the exercise + weight loss group showed significant within-group improvements.

• In terms of CMDS between-group differences, the exercise + weight loss group showed a significant risk reduction when compared with the exercise group.