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Changes in breast density over serial mammograms: A case-control study

European Journal of Radiology Apr 10, 2020

Sartor H, et al. - A case-control study was conducted to explore a potential change in breast density preceding tumor development and the association of this potential change to prognostic pathological tumor variables. Researchers included a sum of 51 consecutive, eligible-for-analyses, biopsy-proven breast cancers were detected between 1 st of August and 31 st of December 2014 at Skåne University Hospital, Sweden. They retrospectively examined mammogram data and patient- and tumor characteristics from medical charts. LIBRA (a free open source software package) was applied to quantitatively estimate breast density. A statistically significant difference was found in density change, where women with breast cancer revealed an increased density over time, which was particularly evident in women > 55 years of age.

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