de la Torre González C, et al. - Researchers assessed the changes that occur in the biofilm of cholesteatoma in pediatric patients following the application of sodium 2-mercaptoethanesulfonate (MESNA). This is the first study demonstrating changes related to cholesteatoma in the structure of the bacterial biofilm following the application of MESNA. The most relevant finding was that after the application of MESNA there were changes in the structure of the biofilm, such as disintegration and separation of the underlying tissue. Chronic infection associated with cholesteatoma could be managed with the observed disintegration of cholesteatoma biofilm ultrastructure.