Minaker SA, Mason RH, Luna GL, et al. - Since diabetic macular oedema (DME) is considered a chronic inflammatory disease associated with aberrations in many intraocular cytokines, researchers sought to evaluate the correlation of cytokines in aqueous samples of patients with DME. They quantitatively summarized data on 116 candidate aqueous and vitreous inflammatory cytokines as biomarkers in DME. A systematic search without year limitation was conducted up to October 19, 2020. Data were gathered from 128 studies, which included 4,163 DME study eyes and 1,281 control eyes. This meta-analysis found that patients with DME had elevated aqueous concentrations of IL-6, IL-8, monocyte chemoattractant protein-1 and vascular endothelial growth factor (VEGF), as well as vitreous concentrations of VEGF.