Singh S, et al. - Given that changes in Gc-globulin (Gc) and in alpha-fetoprotein (AFP) were shown to be related to outcome in patients with acute liver failure (ALF), researchers assessed the markers in comparison and in addition to King's College Criteria (KCC) by performing logistic regression and receiver operating characteristic (ROC) analyses. In this trial of intravenous N-acetylcysteine (NAC) for ALF not due to acetaminophen, sera on days 1 and 3 or days 2 and 4 following admission were available to measure AFP in 70 patients and Gc in 66 patients. According to this retrospective analysis of the double-blind trial, rising AFP but not rising Gc levels was linked to transplant-free survival (TFS) in this comparison of two prognostic markers in patients with non-acetaminophen-induced ALF. In predicting non-TFS, adding declining AFP levels to KCC improved the area under the curve. Gc globulin values did not vary in the two-day intervals studied between TFS and non-TFS.