Matson RIB, Perry R, Hunt LP, et al. - A large-scale systematic review was done to recognize appropriate studies in order to authenticate the change in BMI standard deviation score (BMI-SDS) related to improved inflammation, liver function, and insulin resistance to publish clinical guidelines for pediatric weight management interventions and to evaluate the effectiveness of future trials. Sixty-eight papers were recognized. Across all study subsets (homeostatic model of insulin resistance [HOMA-IR], Glucose, ALT and CRP), greater mean falls in all four parameters were noted with a greater mean loss of BMI-SDS, however, the trends were only statistically meaningful for the HOMA-IR and CRP. Nonetheless, minimum modifications in BMI-SDS that would ensure a fall in these outcomes could not be determined. Thus, in this review, a definitive value of BMI-SDS decrease required to increase the markers of metabolic health could not be suggested.