Ostovaneh MR, Moazzami K, Yoneyama K, et al. - To determine the link between change in N-terminal pro-B-type natriuretic peptide (NT-proBNP) over 3.2 years and incident dementia, researchers analyzed data from Multi-Ethnic Study of Atherosclerosis (MESA) prospective cohort participants (n = 4,563) who were free of cardiovascular disease at enrollment, had NT-proBNP level recorded at MESA exams 1 (baseline, 2000–2002) and 3 (2004–2005), and did not have dementia before exam 3. Overall, 223 dementia cases were reported during 45,522 person-years of follow-up. A 55% rise in the risk of dementia was revealed in multivariable analysis in relation to an increase of at least 25% in NT-proBNP level from MESA exams 1 through 3. The researchers concluded that an increase in NT-proBNP might be independently correlated with future all-cause hospitalized dementia, which may offer a moderately better predictive performance dementia risk vs risk factors and baseline NT-proBNP.