Sturgeon KM, et al. - In a randomized controlled trial, researchers tested the impacts of a 12-month commercially available web-based lifestyle program (Precision Nutrition) on body composition and markers of inflammation. Study participants were BRCA1/2 ⁺, breast cancer survivors, and had completed surgically induced menopause at age <45 years. They observed that the percent change in insulin levels was moderately associated with the percent change in subcutaneous adipose tissue. For the women in the intervention group, the change in subcutaneous adipose tissue was the main driver of change in insulin levels. To alter biomarker levels of inflammation, the change in body composition achieved by the Precision Nutrition program was not sufficient.