Coresh J, et al. - In this large meta-analysis of observational studies, researchers evaluated the consistency of the relationship between change in albuminuria and risk of end-stage kidney disease. Cohort data were eligible if participants were 18 years of age or older, had repeated measurements of albuminuria over an elapsed period of 8 months to 4 years, subsequent kidney disease or mortality follow-up data, and the cohort was active during this consortium phase. For the primary outcome analysis, data for 675,904 individuals and 7,461 end-stage kidney disease events were available. According to findings, change in albuminuria was consistently linked to the subsequent risk of end-stage kidney disease across a range of cohorts, supporting the use of albuminuria change as a substitute endpoint for end-stage kidney disease in clinical studies of progression of chronic kidney disease in the setting of increased albuminuria.