Challenges with colorectal cancer staging: Results of an international study
Modern Pathology Aug 09, 2019
Karamchandani DM, Chetty R, King TS, et al. - A web-based questionnaire representing problematic issues and images associated with colorectal carcinoma staging was circulated among 118 surgical pathologists by the researchers in order to gauge current practice patterns among a diverse group of surgical pathologists. A large number of practicing pathologists neglected recommended-staging criteria in specific settings, especially relative to the evaluation of advanced T stage. Irrespective of the level of experience, the sign-out model, or geographic location, tumors that communicated with the serosa through inflammatory foci were staged as pT3 or pT4a by approximately equal numbers of pathologists. On the basis of the extent of viable tumor, only 65% designated T stage and margin status in the neoadjuvant setting. One-third of pathologists, especially those in Europe, classified acellular mucin deposits as N1 disease when discovered in treatment-naive cases. Approximately 50% of pathologists assigned isolated tumor cells in lymph nodes as metastatic disease. In conclusion, pathologists neglected recommendations that were based on inadequate data and applied individualized criteria when faced with situations that were not directed in the American Joint Committee on Cancer Staging Manual 8th edition. These differences in practice limited the ability to contrast outcome data across various institutions and drew attention to areas that needed additional study.
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