Cervical cancer risk in women living with HIV across four continents: A multicohort study
International Journal of Cancer Jun 26, 2019
Rohner E, et al. - Among women living with HIV who started antiretroviral therapy (ART) between 1996 and 2014, researchers assessed invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin, and North America. In this multicohort study with 64,231 women from 45 countries, 447 in South Africa, 136 in Latin America, 76 in North America and 66 in Europe were the raw ICC incidence rates 100,000 person-years. ICC rates at 5 years post-ART initiation was greater than double in Latin America and 11 times higher in South Africa vs European women; they were comparable in North America. With age and lower CD4 cell counts at ART initiation, an increase in overall ICC rates was observed. In women with HIV, enhancing access to early ART initiation and active cervical cancer screening should be important parts of global efforts in order to decrease cancer-related health inequities.
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