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Cerebellar GABAergic correlates of cognition-mediated verbal fluency in physiology and schizophrenia

Acta Psychiatrica Scandinavica Apr 16, 2019

Piras F, et al. - In patients with schizophrenia (SZ) and matched healthy controls (HC), researchers sought to test the predictive accuracy of a model for the association between cerebellar GABA concentration and the associative/executive processes needed by verbal fluency. Among subcategories in SZ, higher cerebellar GABA concentration was linked to lower phonemic fluency and reduced number of switches vs HC, where higher cerebellar GABA was linked with a higher number of words and phonemic switches. Phonemic fluency in SZ was explained by GABA levels performing above the group mean. This study emphasizes studying cerebellar GABA to explore the molecular mechanisms of SZ which is crucial for developing pharmacological treatments in SZ to improve cognition and functional recovery.

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