Uen YH, et al. - The role of ceramide synthase 6 (CERS6) in gastric cancer (GC) carcinogenesis and prognosis was studied by using RT-PCR, immunoblotting and immunohistochemistry. By employing xenograft proliferation, the impact of CERS6 on tumor growth in animals was determined. A significant correlation of CERS6 overexpression with several clinicopathologic parameters and poor disease-free survival was observed. They also noted that cell proliferation and spread as well as xenograft proliferation were facilitated and suppressed by overexpression and silencing of CERS6 in GC cells, respectively. In mechanistic studies, CERS6, by regulating cell cycle control and metastasis-related protein through the SOCS2/JAK2/STAT3 signaling pathway, impacted cell proliferation and spread. Overall, CERS6 overexpression could have utility as biomarker for predicting the outcomes of GC patients and CERS6 targeting is a potential modality for treating GC.