Moussa MD, et al. - In this prospective, observational cohort study, researchers assessed the ability of biomarkers for PCO₂-based tissue dysoxia, blood lactate concentration and central venous oxygen saturation measured 2 hours after ICU admission as major postoperative complications (MPC) predictors. At admission to ICU and after 2, 6 and 24 h, they included adult patients undergoing cardiac surgery with cardiopulmonary bypass and measured biomarkers of dysoxia. In 56.5% of the 308 patients analyzed, MPC occurred. After cardiac surgery with cardiopulmonary bypass, the only dysoxia biomarker independently associated with MPC, but with limited performance, was central venous-to-arterial PCO₂ difference (ΔPCO₂) measured 2 h after ICU admission.