McCoy IE, et al. - As central venous pressure (CVP) can be used to assess volume status and the risk of acute kidney injury (AKI) when prescribing diuretics in the postcardiac surgical intensive care unit (ICU), researchers investigated the variation in the risk of diuretic-associated AKI in correlation with CVP in patients undergoing cardiac surgery. the Medical Information Mart for Intensive Care database yielded data from 4,164 patients who were admitted to the postcardiac surgical ICU at an urban, academic medical center between 2001 and 2012 and were receiving intravenous loop diuretics. The analysis revealed the independent value of higher rather than lower CVP as a marker of AKI risk. CVP seemed not influencing the risk of AKI associated with diuretic use. Findings support the necessity for novel methods of assessing volume status and AKI risk to escort patient selection for diuretic therapy.