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Central venous access devices for the delivery of systemic anticancer therapy (CAVA): A randomised controlled trial

The Lancet Jul 25, 2021

Moss JG, Wu O, Bodenham AR, et al. - Researchers compared three devices, Hickman-type tunnelled catheters (Hickman), peripherally inserted central catheters (PICCs), and totally implanted ports (PORTs), in terms of complication rates and costs in order to establish acceptability, clinical effectiveness, as well as cost-effectiveness of the devices for patients receiving systemic anticancer treatment (SACT). Participants included adults (aged ≥18 years) undergoing SACT (≥12 weeks) for solid or haematological malignancy, who were recruited from 18 oncology units in the UK. For PICCs and Hickman, the observed complication rates were similar. A complication rate of 29% vs 43% was noted for PORTs vs Hickman. The complication rate for PORTs vs PICCs was 32% vs 47%. Findings showed more effectiveness as well as safety of PORTs, than both Hickman and PICCs, for most patients receiving SACT. On the basis of results of this study, most patients undergoing SACT for solid tumours should receive a PORT within the UK National Health Service.

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