Kim MS, et al. - Researchers investigated if there existed any relationship between central sensitization (an abnormal enhancement of pain mechanism involving the central nervous system) and high wound complication rate in patients who underwent primary total knee arthroplasty (TKA). The likelihood of postoperative wound complications was increased 15.7 times in patients with central sensitization inventory score ≥40. Overall, central sensitization was identified as a risk factor for the development of postoperative wound complication following primary TKA.