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Central and non-central networks, cognition, clinical symptoms, and polygenic risk scores in schizophrenia

Human Brain Mapping Sep 15, 2017

Alloza C, et al. - The aim of this study was to explore the associations between brain structural connectivity as described by network analysis, intelligence, symptoms, and polygenic risk scores (PGRS) for schizophrenia in a group of patients with schizophrenia and a group of healthy controls. The results revealed that intelligence deficits are correlated with a genetic risk for schizophrenia, which is mediated via the disruption of distributed brain networks.
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