Timur UT, et al. - A comparison was performed between the release profile of prostanoids (involved in inflammation), of Hoffa's fat pad (HFP) from osteoarthritis (OA) patients with the individuals having a focal cartilage defect (CD) without evidence for OA on MRI. The prostanoid modulatory anti-inflammatory action of celecoxib on HFP was also assessed by the experts. Findings revealed that in knee OA patients with inflamed HFP's, positive effects could be exerted by celecoxib in the knee joint by reducing the release of prostanoids produced by the HFP and by favorably modulating the anti-inflammatory marker expression in HFP.