Shen J, Medeiros LJ, Li S, et al. - Researchers intended to report that most ALCL cases express CD4, but a small subset of ALCL cases has been described to express CD8. Researchers explored CD8 in 158 individuals with systemic ALCL: CD8 was positive in 13 of 67 (19%) ALK+ and 13 of 91 (14%) ALK-negative neoplasms. It was demonstrated that CD8+ ALCL cases seem to be biologically different from the more common CD8-negative ALCL cases. As per the results, the CD8+ subgroup more often revealed a non-common morphologic pattern and was more often positive for CD2, CD3, and CD7, but less frequently positive for CD25, in ALK+ ALCL. Although there was no effect on survival in this cohort, the data showed that CD8 positivity in ALK+ ALCL helps to distinguish an individual subset more prone to relapse or more in requirement of stem cell transplant during their clinical course.