Shibao CA, et al. - Whether the minor allele (G) of coding CD36 variant rs3211938 (G/T), which reduces CD36 level by ∼50%, influences hormonal responses to a high-fat meal (HFM) was investigated in this analysis. In the preabsorptive hormone and bile acid (BA) responses that coordinate brain and gut regulation of energy metabolism, CD36 played an important role.

Methods

• Before and after a HFM, obese African American (AA) women carriers of the G allele of rs3211938 (G/T) and weight-matched noncarriers (T/T) were examined in this two-center study.
• Study participants were obese AA women.
• Intervention included HFM.
• Researchers determined early preabsorptive responses (10 minutes) and extended excursions in plasma hormones [C-peptide, insulin, incretins, ghrelin fibroblast growth factor (FGF)19, FGF21], BAs, and serum lipoproteins (chylomicrons, very-low-density lipoprotein).

Results

• The study results showed that G-allele carriers had significantly reduced cholesterol and glycodeoxycholic acid and consistent but nonsignificant reductions of serum lipoproteins at fasting.
• It was observed that levels of GLP-1 and pancreatic polypeptide (PP) were reduced 60% to 70% and those of total BAs were 1.8-fold higher.
• G-allele carriers showed attenuated early (-10 to 10 minute) responses in insulin, C-peptide, GLP-1, gastric inhibitory peptide, and PP after the meal.
• According to the findings obtained, BAs showed divergent trends in G allele carriers vs noncarriers concomitant with differential FGF19 responses.