Schluter A, et al. - This inquiry was set up to investigate if the number of microvessels and the expression level of vascular endothelial growth factor (VEGF) in the primary tumor are correlated with the degree of lymph node metastasis (N-stage), tumor staging (T) and survival time in patients with squamous cell carcinoma of the larynx (LSCC). A high expression of angiogenic biomarkers was found to be related to reduced survival and an increased rate of recurrence only in the early stage subgroup. Therefore, biomarkers of angiogenesis may be useful to identify high risk patients specifically in early stage LSCC.