Cavalla F, et al. - CCR5Δ32 (rs333) is a loss-of-function mutation in the CCR5 gene, which can potentially modulate the host response and, consequently periodontitis outcome. In this current investigation, researchers determined the impact of the CCR5Δ32 mutation over the risk to suffer periodontitis. Presence of CCR5Δ32 mutant allele provided significant protection against the development of chronic and aggressive periodontitis. In addition, no significant changes were observed in the presence or quantity of the periodontal pathogens P. gingivalis, T. forsythia, and T. denticola in the subgingival biofilm that could be attributable to the mutant genotype.