Tenno M, et al. – In order to figure out if Cbf{beta}2 deficiency preserves Langerhans cell (LC) precursors by lack of selective TGF{beta} receptor signaling, experts conduct this work. An essential requirement for the Cbfβ2 variant in LC differentiation has been revealed by this study. Data offer insight into how the establishment and homeostasis of the LC network is regulated.