da Rosa GP, et al. - Through a retrospective analysis of systemic lupus erythematosus (SLE) subjects hospitalized in the Department of Autoimmune Diseases of a university hospital during a 20-year period (1995–2015), experts assessed causes and factors associated with hospitalizations in patients with SLE. A total of 814 hospitalizations involving 339 cases were evaluated. Flare, infection, diagnostic procedures and thrombotic events were the main reasons for admission. Therapy with cyclophosphamide was correlated with admission due to infection, while antimalarials demonstrated a protective influence. With related antiphospholipid syndrome persisting as a predicting factor for the outcome, about 3.9% of subjects needed admission to an intensive care unit. Readmission at 30 days was seen in 5.8% of cases and thrombocytopenia and renal involvement were the predicting factors for it. a total of 8 victims died with antiphospholipid syndrome and thrombocytopenia was found out to be correlated with mortality. No notable difference in subjects' demographics or admission causes across the 20-year period were discovered, except for a reduction in admissions because of thrombotic and musculoskeletal causes. A rise in the use of mycophenolate mofetil and lower doses of glucocorticoids were seen, recently. Hence, changes in therapy patterns were recognized, however, the demographics of SLE hospitalizations had no significant change over the past 20 years. Further, predictors of poor outcome were thrombocytopenia, antiphospholipid syndrome, and renal involvement.