Chen W, Cai X, Yan H, et al. - Findings from this Mendelian randomization (MR) analysis demonstrate a causal impact of genetically predicted obstructive sleep apnea (OSA) on an elevated risk of atrial fibrillation.

• By employing a 2‐sample MR method, the causal impact of OSA on atrial fibrillation was assessed by utilizing data from two genome‐wide association studies (with 217,955 and 1,030,836 participants, respectively).

• In both the fixed‐effect and random‐effect inverse‐variance weighted models, MR analyses revealed an elevated risk of atrial fibrillation in relation to genetically predicted OSA (odds ratio [OR], 1.21; OR, 1.21), using 5 single nucleotide polymorphisms as the instruments.

• MR‐Egger suggested no evidence of genetic pleiotropy, and robust results were obtained using other MR methods in sensitivity analyses.