Jovanovic M, Paunovic I, Zdravkovic V, et al. - From 2004 until 2017, researchers conducted a retrospective case-control study in high volume endocrine surgery center to compare biochemical and clinical features of juvenile and adult primary hyperparathyroidism patients. In total, 14 patients with the age ≤ 20 years were involved in the juvenile group, while 28 patients older than 20 were chosen for the control group. The bone disease was the most common form of the disease in juveniles and most adults were asymptomatic. In juvenile and adult patients, the clinical manifestations of primary hyperparathyroidism differ significantly. Juvenile primary hyperparathyroidism is a more severe form of the disease, often with end-organ damages, and should be treated in patients with unspecific symptoms.