CASC11 overexpression predicts poor prognosis and regulates cell proliferation and apoptosis in ovarian carcinoma
Cancer Management and Research Jan 29, 2020
Cui Y, et al. - Given that CASC11 can act as a promotor of colorectal cancer, but the function of CASC11 in ovarian carcinoma (OC) continues to be elusive, so, researchers analyzed both OC and healthy control samples, using qPCR, to measure the expression levels of CASC11 and miR-182. Using cell apoptosis assay, cell apoptosis was examined, and via survival curve analysis, the prognostic value of CASC11 for OC was investigated. The upregulation of CASC11 and microRNA-182 (miRNA-182) was noted in OC. A close correlation of high plasma levels of CASC11 with poor survival conditions of OC patients was revealed. Experts found that CASC11 and miRNA-182 overexpression resulted in promotion of cancer cell proliferation and inhibition of cancer cell apoptosis. Overall, findings revealed CASC11 overexpression as a predictor of poor prognosis in OC and CASC11 as a regulator of cell proliferation and apoptosis as well as microRNA-182 expression in OC.
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