Welby JP, Kim ST, Carr CM, et al. - A total of 143 individuals with connective tissue disease and 143 controls were involved in this study in order to discover the prevalence of carotid artery tortuosity in such individuals in regards to matched controls. Individuals with previous CTA or MRA and a diagnosis of connective tissue diseases were recognized. Specific diagnoses comprised Marfan (n = 33), nonvascular Ehlers-Danlos (n = 36), Ehlers-Danlos vascular-type (n = 32), neurofibromatosis type 1 (n = 26), and Loeys-Dietz (n = 16) syndromes. Carotid artery tortuosity was found out to be highly correlated with connective tissue diseases, especially Marfan syndrome, Loeys-Dietz syndrome, and neurofibromatosis type 1. In connective tissue disease, endovascular treatment planning, and in understanding the pathomechanisms of vascular tortuosity in general, such findings were appropriate in risk evaluation for vascular complications.