Chu LC, et al. - Experts assessed if carotid arterial tortuosity can act as a marker of disease severity in Loeys-Dietz syndrome (LDS) by retrospectively identifying 54 LDS patients who had computed tomogram angiography from January 2004 to December 2013. In patients with LDS, increased carotid artery tortuosity correlated with the need for early aortic root replacement. Results of this study suggested that patients with higher carotid artery tortuosity index were more likely to require aortic root replacement in both aortic root size strata.