Franco LF, Szarf G, Dotto RP, et al. - This research sought to calculate cardiovascular risk by coronary artery calcification (CAC) score in this group. Researchers examined a total of 29 glucokinase -Maturity-Onset Diabetes of the Young (GCK-MODY) cases, 26 normoglycemic controls (recruited among non-affected relatives/spouses of GCK mutation carriers), and 24 unrelated individuals with type 2 diabetes. Individuals who had undergone CAC score evaluation by computed tomography and were categorized by Agatston score ≥ or < 10. They calculated Framingham Risk scores of CAD in 10 years. In GCK-MODY, the CAC score is similar to control individuals from the same family and/or household and is significantly lower than type 2 diabetes. These findings may contribute to understanding the specific effect of hyperglycemia in CAD, besides demonstrating a low risk of CAD in GCK-MODY.