Kario K, Hoshide S, Narita K, et al. - Ambulatory blood pressure (BP) monitoring-detected true resistant hypertension was revealed as a significant independent risk factor for cardiovascular disease events, particularly for heart failure (HF). This emphasizes the value of diagnosing and effectively treating resistant hypertension.

• Resistant hypertension represents a crucial cardiovascular risk factor.

• The JAMP study (Japan Ambulatory Blood Pressure Monitoring Prospective) data for patients with hypertension and no HF history were analyzed to determine how uncontrolled resistant hypertension diagnosed using ambulatory BP monitoring can impact the risk of HF and overall cardiovascular events.

• Participants had true resistant hypertension, pseudoresistant hypertension, well-controlled nonresistant hypertension, or uncontrolled nonresistant hypertension.

• Significantly elevated adjusted risk of total cardiovascular and HF events was evident in patients with true resistant vs controlled nonresistant hypertension (hazard ratios, 1.66 and 2.24, respectively) and vs uncontrolled nonresistant hypertension (1.51 and 3.03, respectively).