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Cardiovascular outcomes and all-cause mortality following measurement of endogenous testosterone levels

American Journal of Cardiology Mar 15, 2019

Adelborg K, et al. - In this cohort study performed in the Central Denmark Region, researchers assessed the 5-year risks of cardiovascular outcomes, including stroke (ischemic and hemorrhagic), myocardial infarction (MI) and venous thromboembolism (VTE), and all-cause mortality among men with a first-ever laboratory testosterone result. Overall 4,771 men with low testosterone levels and 13,467 with normal levels were compared. Higher 5-year risks of stroke, MI, VTE, and all-cause mortality were observed among persons with low testosterone vs those with normal testosterone levels. Overall, cardiovascular outcomes and all-cause mortality in unadjusted models were robustly predicted by low testosterone level, however, once age and comorbidity were adjusted, only the link between low testosterone and all-cause mortality persisted.

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